노현주
  • 이학박사
  • 노현주
  • Hyunju Ro, Ph.D.
  • 세포분화학
  • 생명시스템과학대학 409호
  • 세포분화학실험실(N11-410호)
  • 042-821-5496
  • rohyunju@cnu.ac.kr

학력

  • 박사 (2003), 충남대학교 생물학과 동물학 전공

경력

  • 박사후 과정, 2004. 3 - 2005. 8, 의학 및 세포 및 발달 생물학과, Vanderbilt University School of Medicine, Nashville, TN, USA NIH-NICHD-PGD, USA
  • 연구원, 2009. 3 - 2012. 2, NIH-NICHD-PGD, USA

관심분야

  • Binary or singular Gene switch system

    • 형질전환 동물 제작을 위한 세포 독성이 없는 binary 유전자 발현시스템 개발
    • 세포주 구축을 위한 singular 유전자 발현 시스템 구축
  • 단백질 항상성 연구

    • HSP90에 의한 UPS 단백질 기능 조절 과정
    • UPS 물질 동정
  • 유전자 가위

    • TALEN, RGEN을 이용한 유전자 KO

연구업적

  • Lee, S., Won, M., Hwang, R.H., Hur, G.M., Ro, H. (2018) An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness. J. Vis. Exp. 135, e57494
  • Lee, S., Ro, H., In, H.J., Choi, J.H., Kim, M.O., Lee, J., Hong, S.T., Lee, S.U. (2018) Fisetin inhibits TNF-α/NF-κB-induced IL-8 expression by targeting PKCδ in human airway epithelial cells. Cytokine 108, 247-254
  • Lee, SU., Lee, S., Ro, H., Choi, J.H., Ryu, H.W., Kim, M.O., Yuk, H.J., Lee, J., Hong, S.T., Oh, S.R. (2018) Piscroside C inhibits TNF-α/NF-κB pathway by the suppression of PKCδ activity for TNF-RSC formation in human airway epithelial cells. Phytomedicine 40, 148-157
  • Lee, S., Sohn, K.C., Choi, D.K., Won, M., Park, K.A., Ju, S.K., Kang, K., Bae, Y.K., Hur, G.M., Ro, H. (2016) Ecdysone Receptor-based Singular Gene Switches for Regulated Transgene Expression in Cells and Adult Rodent Tissues. Mol. Ther. Nucleic Acids 5, e367
  • Won, M., Ro, H., Dawid, I.B. (2015) Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas. Proc. Natl. Acad. Sci. U S A 112, 12426-12431.
  • Ro, H., Hur, T-L., Rhee, M. (2015) Ubiquitin conjugation system for body axes specification in vertebrates. 19, 87-95
  • Kim, M., Rhee, M., Ro. H. (2014) Lnx2b, an E3 ubiquitin ligase, in dorsal forerunner cells and Kupffer’s vesicle is required for specification of zebrafish left–right laterality. Animal Cells Syst. 18, 333-339
  • Kang, N., Won, M., Rhee, M., Ro. H. (2014) Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. Mol. Cells 37, 389-398
  • Zhang, T., Park, K.A., Li, Y., Byun, H.S., Jeon, J., Lee, Y., Hong, J.H., Kim, J.M., Huang, S.M., Choi, S.W., Kim, S.H., Sohn, K.C., Ro, H., Lee, J.H., Lu, T., Stark, G.R., Shen, H.M., Liu, Z.G., Park, J., Hur, G.M. (2013) PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. Nat. Commun. 4, 2062