노재랑
  • 이학박사
  • 노재랑
  • Jaerang Rho, Ph.D.
  • 면역학 및 의학미생물학
  • 생명시스템과학대학 611호
  • 면역학 및 의학미생물학실험실(N11-611호)
  • 042-821-6420, 7546
  • jrrho@cnu.ac.kr

학력

  • 박사(1996) : KAIST 생명과학과 (이학박사)

경력

  • 1996-2000 : Rockefeller University (미국) 연수연구원
  • 2000-2002 : University of Pennsylvania (미국) 연수연구원
  • 2002-현재 : 충남대학교 생명시스템과학대학 미생물·분자생명과학과 교수

관심분야

  • 면역학 분야 (Immunology Field)

    • 염증성질환, 자가면역질환 기작 연구
    • T, B, Macrophage 연관 TNFR, TLR 신호전달 연구
    • B lymphopoiesis 기작 연구를 통한 세포백신 연구
    • 면역질환 연관 유전자적중 및 형질전환동물 개발
  • 골면역학 분야 (Osteoimmunology Field)

    • 파골, 조골세포 기능분석을 통한 골다공증 치료제 개발
    • 파골, 조골세포 분화 연관 신호전달기작 규명
    • 줄기세포 이용 골세포 분화경로 규명
    • 형질전환 및 유전자적중 생쥐 개발 통한 골질환 동물모델 개발
  • 줄기세포 분야 (Stem Cell Biology Field)

    • 유전자적중 줄기세포 개발을 통한 면역 기능 연구
    • 면역세포에 대한 유도줄기세포 (iPS) 개발
    • 유도줄기세포(iPS)의 면역세포 분화연구
  • 분자바이러스학 분야 (Molecular Virology Field)

    • Pathogenic virus의 대량 생산기술 개발
    • RNA virus의 감염, 방어, 백신 개발에 대한 연구
    • 다양한 감염성 질환에 대한 바이러스 백신 플랫폼 개발

연구업적

  • Yu J, Choi S, Kim H, Lee N, Yun H, Kim S, Jeong S, Rho J. Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis. Experimental & Molecular Medicine. 2017. Aug 1. [Epub ahead of print].
  • Yu J, Yun H, Shin B, Kim Y, Park ES, Choi S, Yu J, Amarasekara DS, Kim S, Inoue J, Walsh MC, Choi Y, Takami M, Rho J. Interaction of TRAF6 and Vav3 in the RANK Signaling Complex Enhances Osteoclastogenesis. Journal of Biological Chemistry. 2016. Sep 23;291(39):20643-60.
  • Park ES, Choi S, Shin B, Yu J, Yu J, Hwang JM, Yun H, Chung YH, Choi JS, Choi Y, Rho J. TRAF-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. Journal of Biological Chemistry. 2015. Apr 10; 290(15): 9660-9673.
  • Amarasekara DS, Yu J, Park ES, Choi S, Yu J, Rho J. Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases. Journal of Immunology Research. 2015. May 1. 2015:832127.
  • Shin B, Yu J, Park ES, Choi S, Yu J, Hwang JM, Yun H, Chung YH, Hong KS, Choi JS, Takami M, Rho J. Secretion of a truncated Ostm1 mutant inhibits osteoclastogenesis through downregulation of the Blimp1-NFATc1 axis. Journal of Biological Chemistry. 2014. Dec 26;289(52):35868-81.
  • Park ES, Kim J, Ha TU, Choi JS, Hong KS & Rho J. 2013. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Experimental & Molecular Medicine. 45. e35.
  • Yu J, Choi S, Park ES, Shin B, Yu J, Lee SH, Takami M, Kang JS, Meong H, Rho J. 2012. D- chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. J. Clinical Immunology. 32(6):1360-71.
  • Yu J, Shin B, Park ES, Yang S, Choi S, Kang M, Rho J. 2009. Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG- box methylation. Biochemical and Biophysical Research Communication. 391(1):322-8.
  • Lee SH, Kim T, Park ES, Yang S, Jeong D, Choi Y, Rho J. 2008. NHE10, an osteoclast- specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival. Biochemical and Biophysical Research Communication. 369(2):320-6.
  • Park ES, Choi S, Kim JM, Jeong Y, Choe J, Park CS, Choi Y, Rho J. 2007. Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. Biochemical and Biophysical Research Communication. 363(4):971-7.