Jeong Keun Ahn
  • Ph. D.
  • Jeong Keun Ahn
  • Virology & Molecular Genetics
  • N11-613
  • Laboratory of Molecular Virology (N11-613)
  • +82-42-821-6418, 7555
  • jkahn@cnu.ac.kr

Academic Career

  • Ph. D., 1990, Yale University, USA Department of Molecular Biophysics & Biochemistry

Career

  • Post-Doc., 1990-1991, Microbiology & Molecular Genetics, Harvard Medical School, USA

Research Interests

  • The functional analysis of Hepatitis B virus X protein

    Human hepatitis B virus (HBV) is a major pathogen for liver diseases including cirrhosis and hepatocellular carcinoma. Among the HBV proteins, X protein plays critical roles in HBV replication and liver oncogenesis. However, the promiscuous functions of HBx are not elucidated yet. We are trying to validate the various regulatory functions of HBx protein in transcriptional transactivation, signal transduction, and carcinogenesis.

    Hepatitis B virus
  • The regulatory mechanisms of HSV-1 viral proteins

    Herpes simplex virus type 1 (HSV-1) is a neurotropic virus which causes a variety of diseases in human. Among immediate early proteins of HSV-1, ICP27 is essential for viral replication and has multiple functions at transcriptional and post-transcriptional levels. We are dissecting the functional mechanism of ICP27 in the regulation of signal transduction, apoptosis, and viral reactivation. In addition, we also carry the functional analysis of ICP22 and glycoproteins of HSV-1.

  • Ribozyme and RNA interference

    Ribozymes are catalytic RNA molecules which bind target RNA sequences and cleave them in a sequence specific manner. We are developing the highly efficient ribozymes which are suppressing the specific viral gene expressions.

Selected Publication

  • J.A. Kim, D.K. Choi, J.S. Min, I. Kang, J.C. Kim, S. Kim, J.K. Ahn, VBP1 represses cancer metastasis by enhancing HIF-1alpha degradation induced by pVHL, FEBS J, 285 (2018) 115-126.
  • J.A. Kim, M.S. Choi, J.S. Min, I. Kang, J. Oh, J.C. Kim, J.K. Ahn, HSV-1 ICP27 represses NF-kappaB activity by regulating Daxx sumoylation, BMB Rep, 50 (2017) 275-280.
  • J.A. Kim, J.C. Kim, J.S. Min, I. Kang, J. Oh, J.K. Ahn, HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3theta, BMB Rep, 50 (2017) 257-262.
  • S. Y. Kim, J. K. Kim, H. J. Kim, J. K. Ahn Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. IUBMB Life. 2005 57(9):651-8.
  • Inhibition of Hepatitis B Virus replication by in vitro synthesized by RNA. Bull. Korean Chem. Soc. 2005 26(9):1385-1389
  • J. S. Lee, J. Yu, H. J. Shin, Y. S. Kim, J. K. Ahn, C. K. Lee, H. Poo, C. J. Kim Expression of Hepatitis C Virus Structural Proteins in Saccharomyces cerevisiae. J Microbiol Biotechnol. 2005 15(4):767-771.
  • H. J. Kim, J. K. Ahn The structural Analysis of Hepatitis B virus protein for transactivator activity. Chungnam J. Sciences 2004 31(1):55-64.
  • J. K. Kim , Y.K Kim, J. Hong , S. Y. Kim ., C.K Lee .C. J..Kim , Y. S Kim. J. K. Ahn Isolation of the enhanced neuroviruent HSV-1 strains from korean patients. Virus Genes. 2003 26(2):115-8.
  • J. H. Kim, J. B. Park, P. K. Bae, H. S. Kim, D. W. Kim, J. K. Ahn and C. Lee Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral hymidine kinase-dependent drug-resistance. Antiviral Res. 2002 54(3):163-74.
  • K. Y. So, H. J. Lee, K. I. Lee, H. Y. Lee, K. Im, S.K. Baek, C.J. Kim, J. K. Lee, Y. S. Kim A novel protein to bind HCV core protein : The carboxyl terminus truncated core120 protein of HCV interacts with E7 antigen of human papiloma virus type 18. J Microbiol Biotechnol. 2002 12(5):807-811.
  • H. S. Kim, J. K. Lee, I. H. Yang, J. K. Ahn, Y. I. Oh, C. J. Kim, Y. S. Kim, C. K. Lee Identification of hepatitis C virus core domain inducing suppression of allostimulatory capacity of dendritic cells. Arch Pharm Res. 2002 25(3):364-9.
  • C. S. Jin, M. La, J. K. Ahn, G. Meadows, C. O. Joe Tob-Mediated Cross-Talk between MACKS Phosphorylation and Erb-2 Activation. Biochem Biophys Res Commun. 2001 4;283(2):273-7.
  • S. H. Yim, I. Park, J. K. Ahn, C. Kang Translational Suppression by Hammerhead Ribozymes and Inactive variants in S.cerevisiae. Biomol Eng. 2000 16(6):183-9.
  • Y. J. Lee, J. K. Ahn, J. H. Chung Expression of Murine Poly(A) Binding Protein II Gene in Testis. IUBMB Life. 2000 49(1):57-61.
  • J. H. Ko, B. Cho, J. K. Ahn, Y. Lee, I. Park Probing the functional motifs of Escherichia Coli 5s rRNA in relation to 16s rRNA using a SELEX experiment. Bull. Korean Chem. Soc. 2000 20(11):1335-1339