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교수

교수진

 프로필 사진
이름
김남식 (Kim Namshik)   이메일아이콘
전공
줄기세포 신경재생
연락처
연구실
줄기세포신경재생실험실 (생명시스템과학대학 509호)

경력

2012.01-2017.07: Johns Hopkins Medical Institute, Postdoctoral Fellow
2017.08-2019.08: University of Pennsylvania, Postdoctoral Fellow 
2019.09-2021.12: KAIST 생명과학과 연구조교수
2022.01-2023.08: (주) 씨티엑스 연구소장/CTO
2023.09-현재: 충남대학교 생물과학과 조교수

연구분야 및 주제

뇌발달질환 및 정신질환의 분자기전 연구
- 환자 유래 iPSC를 이용한 질환 모델
- 자폐증/조현병 질환동물 모델을 이용한 질병 기전 연구

퇴행성 뇌질환 치료제 개발을 위한 기초 연구
-파킨슨병 세포 치료제 개발
-알츠하이머 신약 개발

Book Chapter

Jang, H., Moon, J., Kim, N.S.† and Yoon, K.J.† CRISPR/Cas9 technologies to manipulate human induced pluripotent stem cells. Methods in iPSC Technology, Volume 9., 249-287 (2021) († correspondence)

연구업적

1.	Mastwal, S., Li, X., Stowell, R., Manion, M., Zhang, W., Kim, N.S., Yoon, K.J., Song, H., Ming, G.L., Wang, K.H.  Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function. ELife, 13;12:RP87414. doi: 10.7554/eLife.87414. (2023)

2.	Byun, Y.G.*, Kim, N.S.*, Kim, G.*, Jeon, Y., , Y.B., Park, C.W., Kim, K., Jang, H., Kim, J., Kim, E., Han, Y.M., Yoon, K.J., Lee, S.H., Chung, W.S. Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis. Immunity, 12;56(9):2105-2120.e13. (2023) (* equal contribution)

3.	Zhang, F., Yoon, K.J., Kim, N.S., Ming, G.L., Song, H. Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus. Stem Cell Reports, 18 (7), 1468-1481 (2023)

4.	Zhang, F., Yoon, K.J., Zhang, D.J., Kim, N.S., Ming, G.L., Song, H. Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification. Cell Stem Cell, 30 (3), 300-311. e11 (2023)

5.	Kim, N.S., Chung, W.S., Astrocytes regulate neuronal network activity by mediating synapse remodeling. Neuroscience Research, 187, 3-13 (2023)

6.	Kim, N.S.*, Ringeling, F.R.*, Zhou, Y., Nguyen, H.N., Temme, S.J., Lin, Y.T., Eacker, S., Dawson V.L., Dawson, T.M., Xiao, B., Hsu, K.-s., Canzar, S., Li, W., Worley, P., Christian, K.M., Yoon, K.J., Song, H., Ming, G.L. CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDAR complex translation in mouse models of psychiatric disorders. Biological Psychiatry, doi.org/10.1016/j.biopsych.2021.04.023 (2022)

7.	Lee, S.H.*, Kim, N.S.*, Choi, M., Ko, S.Y., Jo, H.R., Seo, J.Y., Kim, Y.S., Kim, J.H., and Son, H.  LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology of Stress, doi: 10.1016/j.ynstr.2021.100373 (2021) (* equal contribution)

8.	Kim, N.S.*, Wen, Z.*, Liu, J.*, Zhou, Y., Guo, Z., Xu, C., Lin, Y.T., Yoon, K.J., Park, J., Cho, M., Kim, M., Wang, X., Yu, H., Salamuru, S., Christian, K.M., Hsu, K.S., Xia, M., Li, Ross, Margolis, R.L., Lu, X-Y., Song, H., Ming, G.L., Pharmacological rescue in patient-iPSC and mouse models with a rare DISC1 mutation. Nature Communications, 30;12(1):2570 (2021) 

9.	Habela, C.W., Yoon, K.J., Kim N.S., Taga, A., Bell, K., Bergles, D.E., Maragakis, N.J., Ming, G.L., Song, H. Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche. J Neuroscience, 40(10) 2015-2024 (2020)

10.	Seong, J., Kim, N.S., Kim, J.A., Lee, W., Seo, J.Y., Yum, M.K., Kim, J.H., Park, I., Kang, J.S., Bae, S.H., Yun, C.H., Kong, Y.Y. Side branching and luminal lineage commitment by ID2 in developing mammary glands. Development, 145(14) pii: dev165258 (2018)

11.	Yoon, K.J.*, Ringeling, F.R.*, Vissers, C.*, Jacob, F., Pokrass, M., Jimenez-Cyrus, D., Su, Y., Kim, N.S., Zhu, Y., Zheng, L., Kim, S., Wang, X., Dore, L.C., Jin, P., Regot, S., Zhuang, X., Canzar, S., He, C., Ming, G.L., Song, H. Temporal control of mammalian cortical neurogenesis by m6A methylation. Cell, 171(4), 877-889 (2017) 

12.	Yoon, K.J., Song, G., Qian, X., Pan, J., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., Ming, G.L. Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell, 21(3), 349-358 (2017)

13.	Zeng, Y.*, Yao, B.*, Shin, J., Lin, L., Kim, N.S., Song, Q., Liu, S., Su, Y., Guo, J.U., Huang, L., Wan, J., Wu, H., Qian, J., Cheng, X., Zhu, H., Ming, G.L., Jin, P., and Song, H. Lin28A binds active promoters and recruits Tet1 to regulate gene expression. Mol. Cell, 61(1),153-60 (2016) 

14.	Berg, D.A.*, Yoon, K.J.*, Will, B., Xiao, A.Y., Kim, N.S., Christian, K.M., Song, H., Ming, G.L. 
Tbr2-expressing intermediate progenitor cells in the adult mouse hippocampus are unipotent neuronal precursors with limited amplification capacity under homeostasis. Frontiers in Biology, 10(3), 262-271 (2015)

15.	Wen, Z.*, Nguyen, H.N.*, Guo, Z.*, Lalli, M.A., Wang, X., Su, Y., Kim, N.S., Yoon, K.J., Shin, J., Zhang, C., Makri, G., Nauen, D., Yu, H., Guzman, E., Chiang, C.H., Yoritomo, N., Kaibuchi, K., Zou, J., Christian, K.M., Cheng, L., Ross, C.A., Margolis, R.L., Chen, G., Kosik, K.S., Song, H., Ming, G.L. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature, 515, 414–418 (2014) 

16.	Yoon, K.J., Nguyen, H.N., Ursini, G., Zhang, F., Kim, N.S., Wen, Z., Makri, G., Nauen, D., Shin, J.H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J.E., Hyde, T.M., Christian, K.M., Rapoport, J.L., Weinberger, D.R., Song, H., Ming, G.L. Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell, 15(1), 79-91 (2014)

17.	Yoon, K.J.*, Lee, H.R.*, Jo, Y.S., An, K., Jung, S.Y., Jeong, M.W., Kwon, S.K., Kim, N.S., Jeong, H.W., An, H.S., Kim, K.T., Lee, K., Kim, E., Kim, J.H., Choi, J.S., Kaang, B.K., Kong, Y.Y. Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain, 5(1), 40 (2012)

18.	Kim, N.S., Kim, H.T., Choi, S.W., Kim, Y.Y., Yoon, K.J., Koo, B.K., Kong, M.P., Shin, J., Cho, Y., Kong, Y.Y. Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. Molecular and Cellular Biology, 31(23), 4775-4788 (2011)

19.	Kwon, M.C., Koo, B.K., Kim, Y.Y., Lee, S.H., Kim, N.S., Kim, J.H., Kong, Y.Y. Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development. J Biol Chem., 284(48), 33634-33641 (2009)

20.	Kwon, M.C., Koo, B.K., Moon, J.S., Kim, Y.Y., Park, K.C., Kim, N.S., Kwon, M.Y., Kong, M.P., Yoon, K. J., Im, S. K., Ghim, J., Han, Y. M., Jang, S., Shong, M., Kong, Y.Y. Crif1 is a novel transcriptional coactivator of STAT3. EMBO J., 27, 642-653 (2008)

21.	Kim, N.S. *, Kim, H.J. *, Koo, B.K., Kwon, M.C., Kim, Y.W., Cho, Y., Yokota, Y., Penninger, JM., Kong, Y. Y. Receptor activator of NF-kB ligand regulates the proliferation of MECs via Id2. Molecular and Cellular Biology, 26(3), 1002–1013 (2006)