Myungchull Rhee
  • Ph. D.
  • Myungchull Rhee
  • Neurogenesis Genetics
  • N11-511
  • Laboratory of Protist Diversity (N11-512)
  • +82-42-821-6278
  • mrhee@cnu.ac.kr

Academic Career

  • Ph.D., 1991, University of Carolina, Columbia, USA

Career

  • Post-Doc., 1991-1995, Genetics, Harvard Medical School, USA
  • Visiting Scholar, 2000-2001, Division of Neuroscience, Harvard University, USA

Research Interests

  • We are currently focusing two questions in zebrafish animal model system;
    (1) What are the essential regulator for differentiation of dopaminergic neurons from progenitors and precursor cells? To search for the essential elements we are conducting dynamic studies by employing transcriptomic analysis, bioinformatics, functional genomic & molecular genetic tools.
    (2) How ubiquitin ligases exert their control over the brain patterning and neuronal differentiation? we have identified CNS-specific ubiquitin ligases and their target proteins.

  • Transcriptomic Analysis of dopaminergic neuronal differentiation

    Molecular networks governing specification of neuronal stem cells as well as terminally differentiation neuronal cells remain to be more elucidated. Thus, we have been conducting new generation sequencing for constructing transcriptomic files, bioinformatics analysis of the trascriptomes for selection of critical genes associated with the differentiation, and functional genomics with engineered nucleases and caspase/ssRNA system.

  • Ubiquitin (Ub) ligases for the brain patterning and left-right asymmetry

    We have identified brain-specific Ub ligases, their targets and regulators. The work has generated networks which are profoundly associated with brain development as well as neuronal differentiation particularly in the central nervous system. We are recently extending the list of the brain-specific E3 ligases and their upstream and downstream partners, which will give rise to more of comprehensive networks for the vertebrate brain development and differentiation.

Selected Publication

  • Kyeong-Won Yoo, Sateesh Maddirevula, Ajeet Kumar, Hyunju Ro, Tae-Lin Huh & Myungchull Rhee. (2017) Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos. Anim Cell Sys. 21(2): 93-99.
  • Sateesh Maddirevula, Mrudhula Anuppalle, Hyunju Ro, Tae-Lin Huh, Junho Choe, Myungchull Rhee. (2017) Retinoic Acid and Notch Modulate Expression Patterns of prune2 in the Zebrafish Embryogenesis. Gene Expression Patterns, 23-24: 45-51
  • Soonil Koun, Jun-Dae Kim, Myungchull Rhee, Myoung-Jin Kim, Tae-Lin Huh. (2016) Spatiotemporal expression pattern of the zebrafish aquaporin 8 family during early developmental stages. Gene Expr Patterns. 21(1):1-6.
  • Yoon-Jung Kim, Young Kang, Hye-Yeon Park, Jae-Ran Lee, Dae-Yeul Yu, Takuya Murata, Yoichi Gondo, Jung Hwan Hwang, Yong-Hoon Kim, Chul-Ho Lee, Myungchull Rhee, Pyung-Lim Han, Bong-Hyun Chung, Hyun-Jun Lee and Kyoung-Shim Kim. (2016) STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance. Exp Mol Med. 2016 Feb 26;48:e212.
  • Hye-Yeon Park, Young-Kyoung Ryu, Yong-Hoon Kim, Tae-Shin Park, Jun Go, Jung Hwan Hwang, Dong-Hee Choi, Myungchull Rhee, Chul-Ho Lee, Kyoung-Shim Kim. (2016). Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model. Neurobiol Dis. 89:169-79.
  • Jun-Dae Kim, Eunmi Kim, Soonil Koun, Hyung-Jin Ham, Myungchull Rhee, Myoung-Jin Kim1, and Tae-Lin Huh. (2015) Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Mol. Cells. 38(6): 580-586
  • Hyunju Ro, Tae-Lin Huh, Myungchull Rhee. (2015) Ubiquitin dependent protein modification in vertebrate body axis specification. Anim. Cells Sys. 19(2)