경력
2023.07 - 현재: 충남대학교 일반대학원 생명과학과 조교수 겸무 2021.09 – 현재: 충남대학교 생명시스템과학대학 생물과학과 조교수 2020.03 – 2021.08: 동국대학교 경주 의생명공학과 조교수 2017.03 – 2020.02: Harvard Medical School, Harvard University, Post-doctoral fellow 2014.03 – 2017.02: The Picower Institute, MIT, Post-doctoral fellow
관심분야
시냅스 가소성과 마약 중독에서 신경세포와 비신경세포의 상호작용 뇌암세포에서 칼슘 신호전달과 침투 기작 신경세포들간 신호전달 기작 소뇌 의존적인 움직임에 관여하는 신경조절 세포기작
연구실적
So JS, Kim H, Han KS (2021) Mechanisms of invasion in glioblastoma: Extracellular matrix, Ca2+ signaling, and glutamate. Frontiers in Cellular Neuroscience Shin HY, Han KS, Park HW, Hong YH, Kim Y, Moon HE, Park KW, Park HR, Lee K, Lee CJ, Kim SJ, Heo MS, Park SH, Kim DG, Paek SH (2021) Tumor spheroids of an aggressive form of central neurocytoma have transit-amplifying progenitor characteristics with enhanced EGFR and tumor stem cell signaling. Experimental Neurobiology Han KS*, Chen CH*, Guo C, Regehr WG (2020) Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling. Nature Neuroscience Nam MH, Won W, Han KS, Lee CJ (2020) Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation. Cellular and Molecular Life Sciences Nam MH*, Han KS*, Lee J*, Won W, Koh W, Bae JY, Woo J, Kim J, Kwong E, Choi TY, Chun H, Lee SE, Kim SB, Park KD, Choi SY, Bae YC†, Lee CJ† (2019) Activation of astrocytic µ-opioid receptors in the hippocampus drives conditioned place preference through glutamatergic signaling. Cell Reports Han KS, Guo C, Chen CH, Witter L, Osorno T, Regehr WG (2018) Ephaptic coupling promotes synchronous firing from cerebellar purkinje cells. Neuron Liu M, Shi R, Hwang H, Han KS, Lewis LD, Brown EN, Xu W (2018) SAP102 regulates synaptic AMPAR function through CNIH-2 dependent mechanism. The Journal of Neurophysiology Woo DH, Bae JY, Nam MH, An H, Ju YH, Won J, Choi JH, Hwang EM, Han KS, Bae YC, Lee CJ (2018) Activation of astrocytic µ-opioid receptor elicits fast glutamate release through TREK-1-containing K2P channel in hippocampal astrocytes. Frontiers in Cellular Neuroscience Nam MH*, Han KS*, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Bae YC†, Lee CJ† (2018) Expression of μ-opioid receptor in hippocampal CA1 astrocytes. Experimental Neurobiology Han KS, Cooke S, Xu W (2017) Experience-dependent equilibration of AMPAR-mediated synaptic transmission during critical period. Cell Reports Lee J, Chun YE, Han KS, Lee J, Woo DH, Lee CJ (2015) Ca2+ Entry is required for mechanical stimulation-induced ATP release from astrocyte. Experimental Neurobiology Park H*, Han KS*, Seo J*, Lee J*, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Palmini RB, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ (2015) Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain Yoon BE, Woo J, Chun YE, Chun H, Jo S, Bae JY, An H, Min JO, Oh SJ, Han KS, Kim HY, Kim T, Kim YS, Bae YC, Lee CJ (2014) Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition. The journal of Physiology Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, Lee CJ, Park JY (2014) A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nature Comminications Park H*, Han KS*, Oh SJ, Jo S, Woo J, Yoon BE, Lee CJ (2013) High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte. Molecular Brain Han KS, Woo J, Park H, Yoon BJ, Choi SW, Lee CJ (2013) Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs. Molecular Brain Oh SJ, Han KS, Park H, Woo DH, Kim HY, Traynelis SF, Lee CJ (2012) Protease activated receptor-1-induced glutamate release in cultured astrocytes is mediated by bestrophin-1 channel but not by vesicular exocytosis. Molecular Brain Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, Park JY, Lee CJ (2012) TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell Han KS, Mannaioni G, Hamill CE, Lee J, Junge C, Lee CJ, Traynelis SF (2011) Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus. Molecular Brain Kang SS*, Han KS*, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, Yoo SH, Chung CK, Park SH, Paek SH, Roh EJ, Lee SJ, Park JY, Traynelis SF, Lee CJ (2010) Caffeine-mediated inhibition of calcium release channel IP3R3 blocks glioblastoma invasion and extends survival. Cancer Research Park H, Oh SJ, Han KS, Woo DH, Park H, Mannaioni G, Traynelis SF, Lee CJ (2009) Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. The Journal of Neuroscience
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