school

응용화학공학과

FACULTY
최유성
  • 이학박사
  • 최유성
  • Yoo Seong Choi, Ph.D.
  • 학사(1998) : 서울대학교 화학공학과 (공학학사)
  • 석사(2000) : 서울대학교 화학공학과 (공학석사)
  • 박사(2005) : 서울대학교 화학공학과 (공학박사)
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관심분야

  • 생체분자공학 연구실(Biomolecular Engineering Laboratory)에서는, 21세기 4차 산업혁명 시대에 발맞추어, 지속적으로 증가하는 세계 인구와 인류의 고령화에 따른 건강한 삶과 삶의 질적 수준 향상을 위한 기술, 화석원료의 의존성을 낮추고 지속가능한 자원을 원료로 인류에게 필요한 화학물질과 에너지를 생산하는 기술, 점점 심화되고 있는 기후변화와 환경문제에 대처하는 기술개발에 적극 동참하여, 생체분자 특히 단백질 기반의 생명공학 기술에 기초한 다양한 유용물질의 확보하고 개량하며, 이를 효율적으로 생산하기 위한 핵심기술을 개발하는 연구를 수행하고 있다.

경력

  • 2005-2006 : 유전공학연구소 박사후 연구원
  • 2006-2008 : University of Illinois at Urbana-Champaign (UIUC) 박사후 연구원
  • 2008-2011 : Pohang University of Science & Technology (POSTECH) 화학공학과 연구 조교수
  • 2011-2015 : 충남대학교 화학공학과 조교수
  • 2015-현재 : 충남대학교 응용화학공학과 부교수
  • 2017-2018 : University of Texas at Arlington 방문교수

연구업적

  • Yoo Seong Choi and Young Je Yoo. Reactivation of Horseradish peroxidase in organic media using solvent evaporation, Korean Journal of Biotechnology and Bioengineering, 14(4), 465 - 469 (1999).
  • Jin Ryon Kim, Yoo Seong Choi and Young Je Yoo. Reactivation of Horseradish peroxidase in organic solvent using extraction, Biotechnology Letters, 22, 485-489 (2000).
  • Yoo Seong Choi, Seung Pil Pack and Young Je Yoo. Development of a plasmid display system using GAL4 DNA binding domain for the in vitro screening of functional proteins, Biotechnology Letters, 27, 1707-1711 (2005).
  • Yoo Seong Choi, Hyun Joo and Young Je Yoo. In vitro selection of high affinity DNA binding protein based on plasmid display technology, Journal of Microbiology and Biotechnology, 15, 1022-1027 (2005).
  • Yoo Seong Choi, Seung Pil Pack and Young Je Yoo. Development of a protein microarray using sequence specific DNA binding domain on DNA chip surface, Biochemical and Biophysical Research Communications, 329, 1315-1319 (2005).
  • Ja Hee Chung, Yoo Seong Choi and Seung Hoon Song and Young Je Yoo. Stabilization of HRP using Hsp90 in water-miscible organic solvent, Korean Chemical Engineering Research, 44, 92-96 (2006).
  • Yoo Seong Choi, Houjin Zhang, Joseph S. Brunzelle, Satish Nair and Huimin Zhao. In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in Aureothin biosynthesis, Proceedings of the National Academy of Sciences of the United States of America, 105, 6858-6863 (2008).
  • Dong Soo Hwang, Kyoung Ro Kim, Seonghye Lim, Yoo Seong Choi and Hyung Joon Cha. Recombinant mussel adhesive protein as a gene delivery material, Biotechnology and Bioengineering, 102, 616-623 (2009).
  • Seonghye Lim, Yoo Seong Choi (equal contribution with 1st author), Young Hoon Song, and Hyung Joon Cha. Salt effects on aggregation and adsorption characteristics of recombinant mussel adhesive protein fp-151, The Journal of Adhesion, 85, 812-824 (2009).
  • Seung Pil Pack, Akihiro Doi, Yoo Seong Choi, Tsutomu Kodaki, and Keisuke Makino. Biomolecular response of oxanine in DNA strands to T4 polynucleotide kinase, T4 DNA ligase, and restriction enzymes, Biochemical and Biophysical Research Communications, 391, 118-122 (2010).
  • Seung Pil Pack, Akihiro Doi, Yoo Seong Choi, Hyong Bai Kim, and Keisuke Makino. Accurate guanine:cytosine discrimination in T 4 DNA ligase-based single nucleotide polymorphism analysis using an oxanine-containing ligation fragment, Analytical Biochemistry, 398, 257-259 (2010).
  • Yoo Seong Choi, Tyler W. Johannes, Michael Simurdiak, Zengyi Shao, Haige Lu, and Huimin Zhao. Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis, Molecular Biosystems, 6, 336-338 (2010).
  • Bum Jin Kim, Yoo Seong Choi (equal contribution with 1st author), Bong-Hyuk Choi, Seonghye Lim, Young Hoon Song, and Hyung Joon Cha. Mussel adhesive protein fused with cell adhesion recognition motif triggers integrin-mediated adhesion and signaling for enhanced cell spreading, proliferation, and survival, Journal of Biomedical Materials Research Part A, 94, 886-892 (2010).
  • Seonghye Lim, Yoo Seong Choi (equal contribution with 1st author), Dong Gyun Kang, Young Hoon Song, and Hyung Joon Cha. The adhesive properties of coacervated recombinant hybrid mussel adhesive proteins, Biomaterials, 31, 3715-3722 (2010).
  • Bong-Hyuk Choi, Yoo Seong Choi, Dong Gyun Kang, Bum Jin Kim, Young Hoon Song, and Hyung Joon Cha. Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides, Biomaterials, 31, 8980-8988 (2010).
  • Seonghye Lim, Kyoung Ro Kim, Yoo Seong Choi, Dae-Kyum Kim, Daehee Hwang and Hyung Joon Cha. In vivo post-translational modifications of recombinant mussel adhesive protein in insect cells, Biotechnology Progress, 27(5) 1390-1396 (2011).
  • Yun Jung Yang, Yoo Seong Choi, Dooyup Jung and Hyung Joon Cha. Expression of redesigned mussel silk-like protein in Escherichia coli, The Korean Journal of Chemical Engineering, 28, 1744-1748 (2011).
  • Yoo Seong Choi, Dong Gyun Kang, Seonghye Lim, Yun Jung Yang, Chang Sup Kim and Hyung Joon Cha. Recombinant mussel adhesive protein fp-5 (MAP fp-5) as a bulk bioadhesive and surface coating material, Biofouling, 27 (7), 729-737 (2011).
  • Chang Sup Kim, Yoo Seong Choi, Wooree Ko, Jieun Lee and Hyung Joon Cha. A mussel adhesive protein fused with the BC domain of protein A is a functional linker material that efficiently immobilizes antibodies onto diverse surfaces, Advanced Functional Materials, 21(21) 4101-4108 (2011).
  • Bong-Hyuk Choi, Yoo Seong Choi, Dong Soo Hwang and Hyung Joon Cha. Facile surface functionalization with glycosaminoglycans by direct coating with mussel adhesive protein, Tissue Engineering part C, 18(1) 71-79 (2012).
  • Im Gyu Kim, Dong Gyun Kang, Byung Hoon Jo, Chang Sup Kim, Yoo Seong Choi and Hyung Joon Cha. Biomineralization-based conversion of carbon dioxide to calcium carbonate using recombinant carbonic anhydrase, Chemosphere, 87:1091-1096 (2012).
  • Bum Jin Kim, Yoo Seong Choi and Hyung Joon Cha. Reinforced Multifunctionalized Nanofibrous Scaffolds Using Mussel Adhesive Proteins, Angewandte Chemie International Edition, 51(3) 675-678 (2012).
  • Yeon Kyung Cha, Young Soo Kim and Yoo Seong Choi. Antimicrobial Peptides as Natural Antibiotic Materials, KSBB Journal, 27:9-15 (2012).
  • Yoo Seong Choi and Young Je Yoo. A hydrophobic and hydrophilic organic solvent mixture enhances enzyme stability in organic media, Biotechnology Letters, 34:1131-1135 (2012.6.1)
  • Yoo Seong Choi, Yun Jung Yang, Byeongseon Yang and Hyung Joon Cha. In vivomodification of tyrosine residues in recombinant mussel adhesive protein by tyrosinase co-expression in Escherichia coli, Microbial Cell Factories, 11:139 (2012).
  • Sang-tae Park, Kyoungseon Min, Yoo Seong Choi and Young Je Yoo. Screening of stable cutinase Fusarium solani pisi using plasmid display system, Biotechnology and Bioprocess Engineering, 17:506-511 (2012).
  • Byeongseon Yang, Dong Gyun Kang, Jeong Hyun Seo, Yoo Seong Choi and Hyung Joon Cha. A comparative study on the bulk adhesive strength of the recombinant mussel adhesive protein fp-3, Biofouling, 29:483-490 (2013).
  • Yun Jung Yang, Yoo Seong Choi (equal contribution with 1st author), Dooyup Jung, Byung Rak Park, Woon Bong Hwang, Hyun Woo Kim and Hyung Joon Cha. Production of novel silk-like protein from sea anemone and fabrication of wet- and electro-spun marine-derived silk fibers, NPG Asia Materials, 5:e50 (2013).
  • Yoo Seong Choi, Young Je Yoo. In vitro evolution of glutathione S-transferase using a plasmid display system based on the GAL4 DNA-binding domain, Biotechnology Letters, 35:1455-1460 (2013).
  • Ji-Young Kang, Lanthe Marie P. Benliro, Ik-Joon Lee, Ji-Young Choi, Jin Joo, Yoo Seong Choi, Dong Soo Hwang, Yong-Ki Hong. Biological characteristics and tissue structure of a crustose coralline lithophyllum alga, Journal of Life Science 23:341-346 (2013).
  • Hyerin Kim, Hyunmi Kim, Yoo Seong Choi. Recent advances in tyrosinase research as an industrial enzyme, KSBB Journal, 29:1-8 (2014).
  • Ji-Young Kang, Ianthe MarieE P. Benliro, Ik-Joon Lee, Ji-Young Choi, Jin Joo, Yoo Seong Choi, Dong Soo HwangG, Yong-Ki Hong. Viability, fatty acid composition, and structure of the coralline alga corallina pilulifera, Botanical Sciences 92:103-109 (2014).
  • Ji-Young Kang, Ji-Young Choi, Jin Joo, Yoo Seong Choi, Dong Soo Hwang, Ji-Young Cho and Yong-Ki Hong. Effects of calcification inhibitors on the viability of the coralline algae Lithophyllum yessoense and Corallina pilulifera, Fisheries and Aquatic Sciences, 17:269-273 (2014).
  • Muhammad Tanvir Hossain Chowdhury, Issa Bangoura, Ji-Young Kang, Ji Young Choi, Jin Joo, Yoo Seong Choi, Dong Soo Hwang, Yong-Ki Hong. Comparison of Ecklonia cava, Ecklonia stolonifera and Eisenia bicyclis for phlorotannin extraction, Journal of Environmental Biology 35:713-719 (2014).
  • Byung Hoon Jo, Jeong Hyun Seo, Yun Jung Yang, Kyungjoon Baek, Yoo Seong Choi, Seung Pil Pack, Sang Ho Oh, and Hyung Joon Cha. Bioinspired silica nanocomposite with autoencapsulated carbonic anhydrase as a robust biocatalyst for CO2 sequestration, ACS Catalysis 4:4332-4340 (2014).
  • In Yeub Hwang, Seung Hwan Lee, Yoo Seong Choi, Si Jae Park, Jeong Geol Na, In Seop Chang, Choongik Kim, Hyun Cheol Kim, Yong Hwan Kim, Jin Won Lee, and Eun Yeol Lee. Biocatalytic conversion of methane to methanol as a key step for development of methane-based biorefineries, Journal of Microbiology and Biotechnology 24:1597-1605 (2014).
  • Byeongseon Yang, Niraikulam Ayyadurai, Hyungdon Yun, Yoo Seong Choi, Byeong Hee Hwang, Jun Huang, Qingye Lu, Hongbo Zeng, Hyung Joon Cha. In vivo residue-specific Dopa-incorporated engineered mussel bioglue with enhanced adhesion and water resistance, Angewandte Chemie International Edition, 53:13360-13364 (2014).
  • Emmanuel Chanco, Yoo Seong Choi, Ning Sun, Michael Vu, Huimin Zhao. Characterization of the N-oxygenase AurF from Streptomyces thioletus Bioorganic & Medicinal Chemistry, 22:5569-5577 (2014).
  • So Yeong Bahn, Byung Hoon Jo, Byeong Hee Hwang, Yoo Seong Choi (co-corresponding), Hyung Joon Cha. Role of Pif97 in Nacre Biomineralization: In vitro characterization of recombinant Pif97 as a framework protein for the association of organic–inorganic layers in nacre, Crystal Growth & Design, 15(8):3666-3673 (2015).
  • Wooho Song, Chang Woo Byuu, Minho Yoon, Ji Hoon Eom, Yoo Seong Choi. Simple purification of BA-RGD protein based on CaCl2/EDTA treatment and inclusion body washing, KSBB Journal, 30(6):291-295 (2015).
  • Chaeyeon Son, Jin Ho Kim, Ji Ha Kim, Yoo Seong Choi. Production of recombinant GG1234-DsRed fusion protein and its effect on in vitro CaCO3 crystallization, KSBB Journal, 30(6):296-301 (2015).
  • Ki-Ha Min, Ryeo Gang Son, Mi-Ran Ki, Yoo Seong Choi (co-corresponding), Seung Pil Pack. High expression and biosilica encapsulation of alkaline-active carbonic anhydrase for CO2 sequestration system development, Chemosphere, 143:128-134 (2016).
  • Ki Baek Yeo, Hyong Bai Kim, Yoo Seong Choi (co-corresponding), Seung Pil Pack. Highly effective detection of inflamed cells using a modified bradykinin ligand labeled with FITC fluorescence, Enzyme and Microbial Technology, 82:191-196 (2016).
  • Wooho Song, So Yeong Bahn, Hyung Joon Cha, Seung Pil Pack, Yoo Seong Choi. Recombinant production of a shell matrix protein in Escherichia coli and its application to the biomimetic synthesis of spherulitic calcite crystals, Biotechnology Letters, 38:809-816 (2016).
  • Chaeyeon Son, Yooho Song, Dong Soo Hwang, Yong-Ki Hong, Jin Joo, Yoo Seong Choi. Recombinant production and biochemical characterization of a hypothetical acidic shell matrix protein in Escherichia coli for the preparation of protein-based CaCO3 biominerals, Korean J. Chem. Eng., 33:2406-2410 (2016).
  • Hyerin Kim, Young Joo Yeon, Yoo Rae Choi, Wooho Song, Seung Pil Pack, Yoo Seong Choi. A cold-adapted tyrosinase with an abnormally high monophenolase/diphenolase activity ratio originating from the marine archaeon Candidatus Nitrosopumilus koreensis, Biotechnology Letters, 38:1535-1542 (2016).
  • Ji-Young Kang, Isa Bangoura, Ji-Young Cho, Jin Joo, Yoo Seong Choi, Dong Soo Hwang and Yong-Ki Hong. Antifouling effects of the periostracum on algal spore settlement in the mussel Mytilus edulis, Fisheries and Aquatic Sciences, 19:34-39
  • Young Hoon Song, Jeong Hyun Seo, Yoo Seong Choi, Do Hyung Kim, Bong-Hyuk Choi, Hyung Joon Cha. Mussel adhesive protein as an environmentally-friendly harmless wood furniture adhesive, Int. J. Adhes. Adhes., 70:260-264 (2016).
  • Yoo Rae Choi, Hyunsu Do, Dawon Jeong, Junetae Park, Yoo Seong Choi. Reaction Stability of the Recombinant Tyrosinase-CNK Originating from the Psychrophilic Marine Microorganism Candidatus Nitrosopumilus Koreensis, Clean Technology, 22:175-180 (2016)
  • Paulos Getachew, Mehader Getachew, Jin Joo, Yoo Seong Choi, Dong Soo Hwang, Yong-Ki Hong. The slip agents oleamide and erucamide reduce biofouling by marine benthic organisms (diatoms, biofilms and abalones), ToxEHS, 8(5):341-348 (2016)
  • Chaeyeon Son, Sun Young Kim, So Yeong Bahn, Hyung Joon Cha, Yoo Seong Choi. CaCO3 thin-film formation mediated by a synthetic protein-lysozyme coacervate, RSC Advances, 7:15302-15308 (2017).
  • So Yeong Bahn, Byung Hoon Jo, Yoo Seong Choi, Hyung Joon Cha. Control of nacre biomineralization by Pif80 in pearl oyster, Science Advances, 3:e1700765 (2017).
  • Hyunsu Do, Eungsu Kang, Byeongseon Yang, Hyung Joon Cha, Yoo Seong Choi. A tyrosinase, mTyr-CNK, that is functionally available as a monophenol monooxygenase, Scientific Reports, 7:17267 (2017).
  • Yoo Rae Choi, Eun Hae Kim, Sujin Lim, Yoo Seong Choi. Efficient preparation of a permanent chitosan/gelatin hydrogel using an acid-tolerant tyrosinase, Biochemical Engineering Journal, 129:50-56 (2018).
  • Eungsu Kang, Sun Young Kim, Yoo Seong Choi. Structural and functional properties of tyrosinases as a type-3 copper enzyme, KSBB Journal, 33:63-69 (2018)
  • Yun Jung Yang, Yoo Seong Choi, Hyung Joon Cha. Bioinspired load-bearing hydrogel based on engineered sea anemone skin-derived collagen-like protein, Biotechnology Journal 1800086 (2018)
  • Eun Hae Kim, Sujin Lim, Tae Eun Kim, In Oh Jeon, Yoo Seong Choi. Preparation of in situ injectable chitosan/gelatin hydrogel using an acid-tolerant tyrosinase, Biotechnology and Bioprocess Engineering 23:500-506 (2018)

저서 및 특허

  • Dong Soo Hwang, Yoo Seong Choi, Hyung Joon Cha "Mussel-derived adhesive biomaterials", Chapter 14 in "Marine Biomaterials", CRC Press, 2011
  • 한국생물공학회 역 (공동 번역) "생화학과 분자생물학(Biochemistry & Molecular Biology 5th)", 신일북스, 2017