발생유전학 분야 (Developmental Genetics Field) :
제브라피쉬를 이용한 인간질환유전체 대량 기능분석
새로운 Wnt signaling inhibitor인 ottogi 유전자 발굴 및 기능분석
섬모세포 특이적으로 발현하는 cheonsa 유전자의 기능분석
신경생물학 분야 (Neuroscience Field) :
동물의 감정 조절 및 자폐증 (autism), 불안 (anxiety) 관련 신규 사이토카인 samdori 유전자군 (sam1-sam5)의 발굴 및 기능연구
간질 (epilepsy) 제브라피쉬 모델 개발 및 신약개발 약물 탐색
기능유전체학 분야 (Functional Genomics Field) :
ZFN, TALEN 및 Cas9 system (유전자가위기술)을 확립하여 세계 최고 수준의 Knock-Out Animal 제작 및 질환유전자 기능분석의 국제 공동연구
경력
1998-2001 : 미국국립보건원 (NIH)
2001-현재 : 충남대학교 생물과학과 교수
연구업적
Establishment of a transgenic zebrafish EF1α:Kaede for monitoring cell proliferation during regeneration. Fish Shellfish Immunol. 2013
CCDC41 is required for ciliary vesicle docking to the mother centriole. Proc Natl Acad Sci U S A. 2013
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res. 2014
FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development. PLoS One. 2014
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014
Induction of clusterin Expression by Neuronal Cell Death in Zebrafish. J Genet Genomics. 2014
Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome. Am J Hum Genet. 2015
Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs. Stem Cells. 2015
IFT46 plays an essential role in cilia development. Dev Biol. 2015
ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons. Hum Mol Genet. 2015
Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol. 2015
An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Hum Genet. 2016
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Sci Rep. 2016
PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A. 2016
Silver nanoparticles enhance wound healing in zebrafish (Danio rerio). Fish Shellfish Immunol. 2017
Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. Oncotarget. 2017
Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism. Mol Autism. 2017
Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017
Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Sci Rep. 2017
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2017
Chd7 is critical for early T-cell development and thymus organogenesis. Am J Pathol. 2018
Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proc Natl Acad Sci U S A. 2018
