Eunhee Kim
  • Ph. D.
  • Eunhee Kim
  • Medical Genetics
  • N11-411
  • Laboratory of Cell Signaling & Tumor Biology (N11-412)
  • +82-42-821-5495, 7542

Academic Career

  • Ph. D., 1990, Tufts University, USA


  • Senior researcher, 1990-1991, Korea Research Institute of Chemical Technology, Korea
  • Professor, 1991-2004, Pai Chai University, Korea
  • Professor, 2005-present, Chungnam National University, Korea

Research Interests

Programmed cell death is a part of the normal life cycle of many cell types and has emerged as an essential regulatory mechanism. Therefore, programmed cell death failure leads to various diseases including neurodegenerative diseases and cancer. Control of cell death can protect neurons from neurodegeneration and sensitize tumor cells to anti- cancer drug treatment. Big pharmaceutical companies put major efforts on developing cell death-regulating drugs. Thus, studying with known genes as targets would be disadvantageous for late-comers. To this end, our laboratory aims to select novel death- regulatory genes and understand their molecular mechanisms.

  • Our lab is interested in
    • Understanding molecular mechanisms of cell death
    • Pathogenesis mechanism of diseases by dysregulation of cell death
    • Drug development related such diseases
  • Current research involves
    • Identification and validation of novel death proteins as drug targets
    • Screening and optimization of small molecules targeting death proteins
    • Development of disease animal models

Selected Publication

  • Ki-Hong Jang, Yun-Ju Do, Tae-Sung Koo, Jun-Sub Choi, Eun Ju Song, Yeseong Hwang, Hyun Ju Bae, Ju-hee Lee, Eunhee Kim. Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease. Experimental Eye Research 180 (2019):8–17
  • Ki-Hong Janga, Taeik Janga, Eunji Sona, Soonjin Choib, Eunhee Kim. Kinase-independent role of nuclear RIPK1 in regulating parthanatos through physical interaction with PARP1 upon oxidative stress. BBA - Molecular Cell Research 1865 (2018):132–141
  • Yun-Ju Do, Seo Young Yun, Min-Young Park and Eunhee Kim. The M458L missense mutation disrupts the catalytic properties of Parkin FEBS Letters. 592 (2018):78–88
  • Soo-Jin Kim, Eunhee Kim & Kyung-Taek Rim*. Comparative analysis of Adam33 mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Insight OncoTM NGS Mol Cell Toxicol. 2018 14:221-231
  • Changsun Yu, Bok-seok Kim, Minyoung Park, Yun-Ju Do, Young-Yun Kong and Eunhee Kim*. FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult. Cell Communication and Signaling. 2018:16-56
  • Jang KH, Do YJ, Son D, Son E, Choi JS, Kim E. 2017. AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration. Cell Death Dis. 8, e2526
  • Yu C, Kim B, Kim E. 2016. FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell Death Differ. 23, 1873-85
  • Sul JW, Park MY, Shin JH, Kim YR, Yoo SE, Kong YY, Kwon KS, Lee YH, Kim E. 2013. Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration. Hum Mol Genet. 8, 1558-1573.