Hee-Moon Park
  • Ph. D.
  • Hee-Moon Park
  • Cell Division Chemistry
  • N11-507
  • Laboratory of Cellular Differentiation (N11-507)
  • +82-42-821-6417, 7553
  • hmpark@cnu.ac.kr

Academic Career

  • Ph. D., 1986. Seoul National University, Korea


  • Post-Doc.,1987.9 -1990.1, NIDDK, NIH, USA
  • Visiting Researcher, 1991.12-1992.2, NINDS, NIH, USA

Research Interests

  • Regulatory circuits of the dual-specificity LAMMER kinase for eukaryotic cell differentiation

    We have found that abolition of a dual-specificity LAMMER kinase exerts profound effects on differentiation of fission yeast Schizosaccharomyces pombe including oxidative stress response, cell division cycle, mating, and so on. Our recent study also revealed that the LAMMER kinase modulates various cellular events by regulating gene-expression and activity of key regulatory proteins in eukaryotic microorganisms. Recently, we found that the LAMMER kinase regulates G1- to S-phase cell cycle progression at transcriptional as well as post-translational level in the fission yeast. At present, we are trying to understand the molecular mechanisms for G1- to S-phase progression and DNA-damage response mediated by LAMMER kinase in fission yeast.

  • Functional analysis of developmental genes in Aspergillus species

    With the aids of various screening technologies such as proteome, DEG (differentially expressed gene) and real-time PCR analysis, we have identified developmental stage-specific genes possibly modulated by the regulatory factors, VeA, NsdD, and etc. in the model filamentous fungus Aspergillus nidulans. At present we are attempting several approaches such as forced mass mating and phospho-proteome analyses to identify novel factors for sexual development in opportunistic human pathogen Aspergillus fumigatus. We are performing the gene disruption with CRISPR/Cas9, suppression test, protein-protein interaction, and morphogenetic analyses in order to characterize function of the genes and regulation mode of gene-expressions in Aspergillus spp.

Selected Publication

  • Kang EH, Song EJ, Kook JH, Lee HH, Jeong BR, and Park HM. 2015. Depletion of ε-COP in the COPI vesicular coat reduces cleistothecium production in Aspergillus nidulans. Mycobiology. 43, 31-36
  • Park BC, Park YH, Yi SH, Choi YK, Kang EH, and Park HM. 2014. Transcriptional regulation of fksA, a β-1,3-glucan synthase gene, by the APSES protein StuA during Aspergillus nidulans development. Journal of Microbiology. 52, 940-947
  • Kang EH, Kim JE, Oh HW, Park HM. 2013. LAMMER kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans. PLOS ONE. 8, e58762
  • Yu EY, Lee JH, Kang WH, Park YH, Kim L, Park HM. 2013. Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK- inhibitor Rum1. Biochem Biophys Res Commun. 432, 80-83.