New cancer drug targets through extensive DNA microassay analysis
To identify new cancer drug targets, we examined global changes in gene expression between tumor biopsies and normal tissues. Several unknown genes were identified as genes exhibiting significant differential expression in multiple human cancer tissues. Among those, we identified a gene, Cancer- upregulated gene 2 (CUG2), which is significantly up-regulated in several human tissues such as ovary and liver. Recent our studies also revealed that CUG2 play multiple roles by interacting with various key proteins including CENP-T, an important regulator in the interaction between kinetochore and mitotic spindle during mitosis, and CSN5, a key regulator in the proteasome-mediated protein degradation. CUG2 may play important regulatory roles in cell division and mitosis by modulating the cellular activities of these interacting proteins. Our goal is to investigate the cellular function of the newly-identified cancer-related genes in tumor biogenesis and to develop potentially promising new targets for cancer therapy.