Postdoctoral Associate, 2017.03 - 2020.02, Department of Life Sciences, POSTECH
Postdoctoral Associate, 2020.03 - 2021.02, Department of Systems Biology, Yonsei University
Research Professor, 2021.03 - 2023.8, Department of Systems Biology, Yonsei University
Assistant Professor, 2023.09 - present, Department of Convergent Bioscience and Informatics, Chungnam National University
Research Interests
Humans consistently interact with trillions of microorganisms, forming a ‘superorganism’. The human microbiota, an assembly of microorganisms on the any surface of human, is heavily influenced by various factors such as the host genetic information, health status, diet, exercise, and medication usage. This interaction, at times beneficial and at other times detrimental, significantly impacts the host's physiological functions.
The Translational Microbiome Laboratory aims to analyze microorganisms in diverse environments, including healthy individuals, patients, rhizosphere, soil, marine, and many other ecosystems. Combining both ‘dry’ techniques such as 16S rRNA gene amplicon sequencing, whole metagenomic sequencing, and ‘wet’ methodologies such as molecular and cell-based experiments, our lab explores microorganisms, their genetic factors, and relevant metabolites associated with human traits and diseases. Ultimately, we aim to elucidate the intrinsic cellular and molecular biological mechanisms, proposing methods for clinical or industrial applications.
Selected Publication
Kim KH§, Chung Y§, Huh JW§, Park DJ, Cho Y, Oh Y, Jeong H, Yoon J, Kang JH, Shin HS, Kim HC, Kwon SK, Seo KY, Oh SH, Seong JK, Ha SJ, Nam KT, Kim JF. Gut microbiota of the young ameliorates physical fitness of the aged in mice. Microbiome. 2022 Dec 26;10(1):238. doi: 10.1186/s40168-022-01386-w. (§co-first)
Huh JW, Kim MJ, Kim J, Lee HG, Ryoo SB, Ku JL, Jeong SY, Park KJ, Kim D, Kim JF, Park JW. Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer. Microbiome. 2022 Nov 28;10(1):203. doi: 10.1186/s40168-022-01388-8.
Huh JW, Roh TY. Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis. BMC Microbiol. 2020 Jul 13;20(1):208. doi: 10.1186/s12866-020-01887-4.
Huh JW§, Shibata T§, Hwang M, Kwon EH, Jang MS, Fukui R, Kanno A, Jung DJ, Jang MH, Miyake K, Kim YM. UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7072-7. doi: 10.1073/pnas.1322838111. (§co-first)
