Kwang-Guk An
  • Ph. D.
  • Kyoung-Mi Kim
  • RNA biology, Cellular Senescence
  • N11-413
  • Laboratory of RNA Genomics (N11-414)
  • +82-42-821-5498
  • km.kim@cnu.ac.kr

Academic Career

  • Ph.D., 2011, Korea University.

Career

  • Postdoctoral fellow, 2013.12-2018.11, National Institute on Aging/ National Institute of Health
  • Research professor, 2011.09-2013.11, Korea University

Research Interests

  • Understanding RNA regulatory mechanism during cellular senescence

    Finding of transcriptome that changes during cellular senescence

    Study of RNA regulators and their mechanism during cellular senescence

  • Understanding the function of Extracellular Vesicles (EVs)

    Study of mechanism and factors involved in biogenesis, secretion, uptake pathway of EVs

    Understanding the RNA components and function of extracellular vesicles during cellular senescence

    Function of extracellular vesicles as biomarkers in age-related disease

Selected Publication

  • Noh JH*, Kim KM*, Pandey PR, Noren Hooten N, Munk R, Kundu G, De S, Martindale JL, Yang X, Evans MK, Abdelmohsen K, Gorospe M. (Mar 2019) Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program. Nucleic Acids Res, 47(5):2472-2486. (*: equally contributed)
  • Noh JH*, Kim KM*, Idda ML*, Martindale JL, Yang X, Abdelmohsen K, Gorospe M. (Aug 2018) GRSF1 suppresses cell senescence. Aging (Albany NY), 10:1856-1866. (*: equally contributed)
  • Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Pandey PR, Yang X, Biragyn A, Abdelmohsen K, Gorospe M. (Jul 2018) SCAMP4 enhances the senescent cell secretome. Genes and Development, 32(13-14):909-914. (*: equally contributed, #: Corresponding author).
  • Noh JH, Kim KM, McClusky WG, Abdelmohsen K, Gorospe M. (Mar 2018) Cytoplasmic functions of long noncoding RNAs. Wiley Interdiscip Rev RNA, 9(3): e1471. Review.
  • Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M. (Sept 2017) Identification of senescent cell surface targetable protein DPP4. Genes and Development, 31(15):1529-1534. (*: equally contributed, #: Corresponding author).
  • Park J, Park Y, Ryu I, Choi MH, Lee HJ, Oh N, Kim K, Kim KM, Choe J, Lee C, Baik JH, Kim YK. (Jun 2017) Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex. Nat Commun, 8:15730.
  • Kim KM#, Abdelmohsen K, Mustapic M, Kapogiannis D, Gorospe M. (Jul 2017) RNA in extracellular vesicles. Wiley Interdiscip Rev RNA, 8(4): e1413. Review. (#: Corresponding author).
  • Kim KM, Noh JH, Abdelmohsen K, Gorospe M. (Apr 2017) Mitochondrial noncoding RNA transport. BMB Rep, 50(4):164-174. Review.
  • Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M. (Apr 2017) Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res, 45(7):4021-4035.
  • Noh JH*, Kim KM*, Abdelmohsen K, Yoon JH, Panda AC, Munk R, Kim J, Curtis J, Moad CA, Wohler CM, Indig FE, de Paula W, Dudekula DB, De S, Piao Y, Yang X, Martindale JL, de Cabo R, Gorospe M. (May 2016) HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP. Genes and Development, 30(10):1224-39. (*: equally contributed).
  • Abdelmohsen K, Panda AC, De S, Grammatikakis I, Kim J, Ding J, Noh JH, Kim KM, Mattison JA, de Cabo R, Gorospe M. (Nov 2015) Circular RNAs in monkey muscle: age-dependent changes. Aging, 7(11):903-10.
  • Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M. (Nov 2014) PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun, 5: 5248.
  • Cho H, Ahn SH, Kim KM, Kim YK. (Jul 2013) Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1. FEBS Lett, 587(14) 2118-24.
  • Choe J*, Kim KM*, Park S, Lee YK, Song OK, Kim MK, Lee BG, Song HK, Kim YK. (Jan 2013) Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Research, 41(2) 1307–1318. (*: equally contributed).
  • Kim KM*, Cho H*, Kim YK. (Aug 2012) The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochem. Biophys. Res. Commun, 424(3) 469-475. (*: equally contributed).
  • Cho H, Kim KM, Han S, Choe J, Park SG, Choi SS, Kim YK. (May 2012) Staufen1-Mediated mRNA Decay Functions in Adipogenesis. Molecular Cell, 46(4):495-506
  • Kim KM*, Cho H*, Choi K*, Kim J, Kim BW, Ko YG, Jang SK, Kim YK. (Sept 2009) A new MIF4G domain-containing protein CTIF directs nuclear cap-binding protein CBP80/20-dependent translation. Genes and Development, 23:2033-2045. (*: equally contributed).
  • Cho H*, Kim KM*, Kim YK. (Jan 2009) Human proline-rich nuclear receptor coregulatory protein 2 (PNRC2) mediates an interaction between mRNA surveillance machinery and decapping complex. Molecular Cell, 33(1), 75-86. (*: equally contributed).