경력
1998-2000 : 박사후 연구원, 알라배마주립대학 (미국, 버밍햄)
2000-2002 : 박사후 연구원, 캘리포니아주립대학 (미국, 샌디에고)
2002-2003 : 연구원, LG Biomedical Institute (미국, 샌디에고)
2003-2004 : 차장, (주)LG생명과학 연구원
2004-현재 : 교수, 충남대학교 미생물·분자생명과학과
연구업적
Joo Y, Kim H, Lee S, and Lee S. Mice lacking neuronal growth regulator 1 (NEGR1) exhibited increased adiposity and reduced muscle mass. Int J Obesity. (In Revision)
Noh K, Lee H, Choi, TY, Joo Y Kim SJ, Kim H, Kim JY, Jahng JW, Lee S*, Choi SY*, Lee SJ*, Negr1 controls adult hippocampal neurogenesis and affective behaviors. Mol Psychiatry. Accepted (*co-corresponding authors)
Min H, Cho WH, Lee H, Choi B, Kim YJ, Lee HK, Joo Y, Jung SJ, Choi SY, Lee S*, Lee SJ*. Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization. Mol Pain. 2018 Jan-Dec;14:1744806918812636. doi: 10.1177/1744806918812636. Epub 2018 Oct 25. (*co-corresponding authors)
Cheon Y, Lee S. Two major alternative splice variants of beta-TrCP1 interact with CENP-W with different binding preferences. Genes Genomics. 2018 Sep 28. doi: 10.1007/s13258-018-0748-3. [Epub ahead of print]
Cheon Y, Lee S. CENP-W inhibits CDC25A degradation by destabilizing the SCFβ-TrCP-1 complex at G2/M. FASEB J. 2018 Oct 30 32 (11):6051-6065. DOI: 10.1096/fj.201701358RRR
Kim H, Chun Y, Che L, Kim J, Lee S, Lee S. The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1367-1374. doi: 10.1016/j.bbrc.2016.12.043.
Cheon Y, Jeon S, Lee S. Centromere protein W interacts with beta-transducin repeat-containing protein 1 and modulates its subcellular localization. FEBS Lett. 2016 Dec;590(24):4441-4452. doi: 10.1002/1873-3468.12483.
Chun Y, Kim R, Lee S. Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells. PLoS One. 2016 Feb 16;11(2):e0149127. doi: 10.1371/journal.pone.0149127. eCollection 2016.
Koh W, Park B, Lee S. A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing. Biochem Biophys Res Commun. 2015 Aug 14;464(1):256-62. doi: 10.1016/j.bbrc.2015.06.136.
Kim H, Hwang JS, Lee B, Hong J, Lee S. Newly Identified Cancer-Associated Role of Human Neuronal Growth Regulator 1 (NEGR1). J Cancer. 2014 Jul 21;5(7):598-608.
Chun Y, Lee M, Park B, Lee S. CSN5/JAB1 Interacts with the Centromeric Components CENP-T and CENP-W and Regulates Their Proteasome-mediated Degradation. J Biol Chem. 2013 Sep 20;288(38):27208-19.
Chun Y, Park B, Koh W, Lee S, Cheon Y, Kim R, Che L, Lee S. New centromeric component CENP-W is a RNA-associated nuclear matrix protein that interacts with nucleophosmin /B23 protein J Biol Chem 2011, 286 (49): 42758–69.
저서 및 특허
Lee S, and Lee SJ. (2007) Chapter VI. Toll-like receptors : Sensor Molecules for infection and Tissue Damage in the Nervous System. P149-168. Neuroimmunology Research Perspectives. Nova Science Publishers, Inc.ISBN-13:978-1-60021-532-2
Subramani S, Damai V, Hezda P, Suriapratana I, and Lee S. (2002) Chapter 12. Import of proteins into peroxisomes, pp 268- 292, Protein Targeting, Transport, and Translocation. Academic Press.